PAEA Surgery End Of Rotation (EOR) Practice Exam

What is a common extraintestinal manifestation related to inflammatory bowel disease?

1. Ankylosing spondylitis

2. Asthma

3. Diabetes

4. Lupus

The correct answer is: Ankylosing spondylitis

Ankylosing spondylitis is a common extraintestinal manifestation associated with inflammatory bowel disease (IBD), particularly Crohn's disease and ulcerative colitis. IBD is known to have systemic effects beyond the gastrointestinal tract, and musculoskeletal complications are among the most frequent extraintestinal manifestations. Ankylosing spondylitis is a type of inflammatory arthritis that primarily affects the spine and the sacroiliac joints, leading to pain and stiffness. It is considered a type of spondyloarthritis, which shares a common pathophysiological background with IBD. The relationship between IBD and ankylosing spondylitis is thought to involve genetic factors, specifically the presence of the HLA-B27 antigen. Around 5-10% of patients with IBD may develop ankylosing spondylitis, illustrating the intertwining nature of these conditions. In contrast, asthma, diabetes, and lupus, while they can occur in individuals with IBD, are not directly linked as extraintestinal manifestations of the disease. Asthma is primarily a respiratory condition, diabetes is related to glucose metabolism, and lupus is an autoimmune disorder that affects multiple organs. These conditions do not have the same direct association with IBD as