PAEA Surgery End Of Rotation (EOR) Practice Exam

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At what stage is lobular carcinoma in situ (LCIS) classified?

Pre-malignant
Invasive malignant
Benign
Metastatic

The correct answer is: Pre-malignant

Lobular carcinoma in situ (LCIS) is classified as a pre-malignant condition primarily due to its association with an increased risk of developing invasive breast cancer in either breast. While LCIS is not considered a form of breast cancer itself, its presence indicates that there are abnormal cells in the lobules of the breast, which can serve as a marker for future malignancy. This classification stems from the understanding that patients diagnosed with LCIS are generally monitored more closely for breast cancer development. In contrast, invasive malignant denotes cancer that has spread beyond its original site and infiltrated surrounding tissues, while benign refers to non-cancerous conditions that do not typically pose a risk for malignancy. Metastatic implies cancer that has spread to distant parts of the body, indicating an advanced stage of the disease. LCIS, being neither invasive nor malignant in itself, does not fit these definitions and highlights its role as a potential precursor to future cancers rather than representing an immediate malignancy.